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Co-Enzyme B Complex – Pharmacokinetics (pk) Study

Bioavailability study

B-vitamins are essential nutrients required for energy production, synthesis of blood cells, healthy nervous system function, and other metabolic processes. Coenzyme B vitamins are the active, coenzyme forms of B vitamins that are utilized by the body in most metabolic reactions. Three healthy adult volunteers 22 to 55 years old participated in a clinical trial to study the bioavailability of Co-Enzyme B-Complex, a dietary supplement from NOW® (item # 0405). Plasma vitamin B2, B3, B5, B6, folate, and B12 were measured at baseline, and 1, 2, 3 and 6 hours following oral administration of two tablets of Co-Enzyme B-Complex.


The average plasma vitamin B5 and folate peaked two hours after supplementation, reaching the levels of 17% and 22% over the baseline, respectively. Average plasma vitamin B2 and B3 peaked at three hours reaching the levels of 60% and 42% over the baseline, respectively. Average plasma vitamin B6 and B12 increased gradually over the period of the study, reaching maximum concentration at six hours, 417% and 10% over the baseline, respectively. The study confirms the bioavailability NOW® Co-Enzyme B-Complex.


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